STUDIES ON SOMATIC CELL MUTATIONS
نویسندگان
چکیده
منابع مشابه
Estimating Cell Depth from Somatic Mutations
The depth of a cell of a multicellular organism is the number of cell divisions it underwent since the zygote, and knowing this basic cell property would help address fundamental problems in several areas of biology. At present, the depths of the vast majority of human and mouse cell types are unknown. Here, we show a method for estimating the depth of a cell by analyzing somatic mutations in i...
متن کاملSomatic mutations and proteins
A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types. Today, I would like to consider how somatic mutations might be genetically predisposed and thereby made available to an organism during its adaptation to e...
متن کاملCSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.
Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to determine the somatic mutational landscape of penile cancer. WES was performed on ...
متن کاملSomatic cell gene mutations in humans: biomarkers for genotoxicity.
Somatic cell gene mutations arising in vivo in humans provide biomarkers for genotoxicity. Four assays, each measuring changes in a different "recorder" gene, are available for detecting mutations of the hemoglobin (Hb) and glycophorin A (gpa) genes in red blood cells and the hypoxanthine-guanine phosphoribosyltransferase (hprt) and HLA genes in T-lymphocytes. Mean adult background mutant frequ...
متن کامل[Haldane's rule and somatic mutations].
Haldane's rule stating that viability and fertility in the heterogametic sex of hybrids are lower than in the homogametic sex is explained on the basis of the assumption that diploidy is aimed at protecting individuals having large body size and large genomes from somatic mutations. The presence of hemizygous sex chromosomes, which are effectively haploid in the heterogametic sex, results in th...
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ژورنال
عنوان ژورنال: The Japanese Journal of Genetics
سال: 1976
ISSN: 0021-504X,1880-5787
DOI: 10.1266/jjg.51.237